Risk assessment of SARS-CoV-2 in Antarctic wildlife

The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pathogen has spread rapidly across the world, causing high numbers of deaths and significant social and economic impacts. SARS-CoV-2 is a novel coronavirus with a suggested zoonotic origin with the potential for cross-species transmission among animals. Antarctica can be considered the only continent free of SARS-CoV-2. Therefore, concerns have been expressed regarding the potential human introduction of this virus to the continent through the activities of research or tourismto minimise the effects on human health, and the potential for virus transmission to Antarctic wildlife. We assess the reverse-zoonotic transmission risk to Antarcticwildlife by considering the available information on host susceptibility, dynamics of the infection inhumans, and contact interactions between humans and Antarctic wildlife. The environmental conditions in Antarctica seem to be favourable for the virus stability. Indoor spaces such as those at research stations, research vessels or tourist cruise ships could allow for more transmission among humans and depending on their movements between different locations the virus could be spread across the continent. Among Antarctic wildlife previous in silico analyses suggested that cetaceans are at greater risk of infection whereas seals and birds appear to be at a low infection risk. However, caution needed until further research is carried out and consequently, the precautionary principle should be applied. Field researchers handling animals are identified as the human group posing the highest risk of transmission to animals while tourists and other personnel pose a significant risk only when in close proximity (< 5 m) to Antarctic fauna. We highlight measures to reduce the risk as well as identify of knowledge gaps related to this issue.Fil: Barbosa, A.. Museo Nacional de Ciencias Naturales; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Varsani, Arvind. Arizona State University; Estados Unidos. University of Cape Town; SudáfricaFil: Morandini, Virginia. State University of Oregon; Estados UnidosFil: Grimaldi, Wray. No especifíca;Fil: Vanstreels, Ralph E.T.. Institute Research And Rehabilitation Marine Animals; BrasilFil: Diaz, Julia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Boulinier, Thierry. Université Montpellier II; Francia. Centre National de la Recherche Scientifique; FranciaFil: Dewar, Meagan. Federation University; AustraliaFil: González Acuña, Daniel. Universidad de Concepción; ChileFil: Gray, Rachael. University Of Western Sydney.; AustraliaFil: McMahon, Clive R.. Sydney Institute Of Marine Science; AustraliaFil: Miller, Gary. University of Western Australia; AustraliaFil: Power, Michelle. Macquarie University; AustraliaFil: Gamble, Amandine. University of California; Estados UnidosFil: Wille, Michelle. University Of Western Sydney.; Australi

Galaxy Groups: Proceedings from a Swinburne University Workshop

We present the proceedings from a 2-day workshop held at Swinburne University on the 24th-25th of May 2005. The workshop participants highlighted current Australian research on both theoretical and observational aspects of galaxy groups. These proceedings include short 1-page summaries of a number of the talks presented at the workshop. The talks presented ranged from reconciling N-body simulations with observations, to the HI content of galaxies in groups and the existence of ``dark galaxies''. The formation and existence of ultra-compact dwarfs in groups, and a new supergroup in Eridanus were also discussed.Comment: to be published in PAS

Macroparasites in Antarctic Penguins

Fil: Díaz, Julia Inés. Centro de Estudios en Parasitología y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Fusaro, Bruno. Instituto Antártico Argentino (IIA); ArgentinaFil: Vidal, Virginia. Departamento de Ecología Evolutiva. Museo Nacional de Ciencias Naturales. CSIC. Madrid; EspañaFil: González-Acuña, Daniel. Facultad de Ciencias Veterinarias. Universidad de Concepción; UruguayFil: Schneider Costa, Erli. Universidade Estadual do Rio Grande do Sul ; BrazilFil: Dewar, Meagan. Deakin University; AustraliaFil: Gray, Rachael. Faculty of Veterinary Science. School of Life and Environmental Sciences. University of Sydney; AustraliaFil: Power, Michelle. Department of Biological Sciences. Macquarie University; AustraliaFil: Miller, Gary. Institute for Marine and Antarctic Studies. University of Tasmania; TasmaniaFil: Blyton, Michaela. Western Sydney University; AustraliaFil: Vanstreels, Ralph. Department of Pathology. Faculty of Veterinary Medicine and Animal Science. University of SÆo Paulo; BrazilFil: Barbosa, Andrés. Departamento de Ecología Evolutiva. Museo Nacional de Ciencias Naturales. CSIC. Madrid; Españ

Knowledge, Perceptions and Information about Hormone Therapy (HT) among Menopausal Women: A Systematic Review and Meta-Synthesis

BACKGROUND: The use of hormone therapy (HT) by menopausal women has declined since the Women's Health Initiative randomized trial (WHI) in 2002 demonstrated important harms associated with long-term use. However, how this information has influenced women's knowledge and attitudes is uncertain. We aimed to evaluate the attitudes and perceptions towards HT use, as well as specific concerns and information sources on HT since the WHI trial. METHOD/RESULTS: We did a systematic review to assess the attitudes and knowledge towards HT in women, and estimate the magnitude of the issue by pooling across the studies. Using meta-synthesis methods, we reviewed qualitative studies and surveys and performed content analysis on the study reports. We pooled quantitative studies using a random-effects meta-analysis. We analyzed 11 qualitative studies (n = 566) and 27 quantitative studies (n = 39251). Positive views on HT included climacteric symptom control, prevention of osteoporosis and a perceived improvement in quality of life. Negative factors reported included concerns about potential harmful effects, particularly cancer risks. Sources of information included health providers, media, and social contact. By applying a meta-synthesis approach we demonstrate that these findings are broadly applicable across large groups of patients. CONCLUSIONS: Although there are clear hazards associated with long-term HT use, many women view HT favorably for climacteric symptom relief. Media, as a source of information, is often valued as equivalent to health providers

Comment letters to the National Commission on Commission on Fraudulent Financial Reporting, 1987 (Treadway Commission) Vol. 2

https://egrove.olemiss.edu/aicpa_sop/1662/thumbnail.jp

The Go-GN Open Research Handbook

This Handbook draws together work done between 2020 and 2023 by members of the Global OER Graduate Network (GO-GN). GO-GN is a network of PhD candidates around the world whose research projects include a focus on open education. GO-GN is currently funded through the OER programme of The William and Flora Hewlett Foundation and administered by the Open Education Research Hub from the Institute of Educational Technology at The Open University, UK. In our current phase of activity, we began these collaborative writing efforts with a Research Methods Handbook which was created during the depths of the Covid-19 pandemic. Working together at distance provided an important way to strengthen community links when meeting in person was not possible. The Research Methods Handbook was well received by a much larger audience than we anticipated, and went on to win an Open Research Award. We followed this up with a sister publication, our Conceptual Frameworks Guide. This explores a less well traversed (but nonetheless important) area of scholarly focus. Together, these two explore open approaches to the theory and practice of research in open education. One distinctive feature of our presentation is to foreground the authentic experiences of doctoral researchers who have used specific approaches in researching open education. While it is not possible to cover all approaches in this detail, we hope that important insights are presented in this form of open practice. Throughout 2020-2022 we also regularly engaged our membership through collective reviews of recently published papers and articles. The Research Reviews serve as an overview of recent research but also as a snapshot of the critical responses recorded by doctoral and post-doctoral researchers working in relevant areas. No one volume can claim to comprehensively contain the diversity and variety of open approaches, and this is no exception. But one virtue of openness is that we can draw on the openly licensed works of others to increase our coverage of relevant areas. The Additional Resources at the end of this volume bring together a range of openly licensed texts on open education research and suggests places for further reading and research. Consequently, the information contained here represents a wide range of contributors and collaborators. The original and intended audience for this volume is the doctoral student working on an open education research project - in short, the typical student member of GO-GN and the profile the network exists to support. However, we’ve learned through feedback and analytics that the potential audience for works like this is much larger. Many people who wouldn’t describe themselves as researchers still do research and evaluation. Presenting accessible insights into research foundations and practices helps with this and can be understood as a form of open practice

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe